Recombinant Human CD300 antigen protein (Fc Chimera His Tag) (ab185418)

Overview

Description

  • Nature
    Recombinant
  • Source
    Mammalian
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      LSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGS AGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPV VEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASI QEETEEVVNSQVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPP KPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQ YNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTP PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GKHHHHHH
    • Molecular weight
      45 kDa including tags
    • Amino acids
      18 to 178
    • Additional sequence information
      FC-6xHis tag at the C-terminus.

Specifications

Our Abpromise guarantee covers the use of ab185418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilised protein in 3X PBS. Please aliquot the reconstituted solution and store at < -20 degrees, avoid freeze/thaw cycles.

General Info

  • Alternative names
    • CD300 antigen-like family member A
    • CD300a
    • CD300a antigen
    • CD300a molecule
    • CLM-8
    • CLM8_HUMAN
    • CMRF 35 H9
    • CMRF-35-H9
    • CMRF35-H
    • CMRF35-H9
    • CMRF35-like molecule 8
    • CMRF35H
    • CMRF35H leukocyte immunoglobulin like receptor
    • CMRF35H9
    • IgSF12
    • Immunoglobulin superfamily member 12
    • Inhibitory receptor protein 60
    • IRC1
    • IRC1/IRC2
    • IRC2
    • IRp60
    • Leukocyte membrane antigen
    • Mast cell derived paired immunoglobulin like receptor 1
    • NK inhibitory receptor
    • Polymeric immunoglobulin receptor 4
    see all
  • Function
    Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
  • Tissue specificity
    Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
  • Sequence similarities
    Belongs to the CD300 family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Phosphorylated on tyrosine.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab185418 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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