Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQW SDIEEFCNR
    • Amino acids38 to 96

Specifications

Our Abpromise guarantee covers the use of ab80038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • ReconstitutionRedissolve the powder with 1ml sterile water will restore to the original concentration 1mg/ml.

General Info

  • Alternative names
    • CD 55
    • CD55
    • CD55 antigen
    • CD55 Cromer blood group system
    • CD55 molecule
    • CD55 molecule, decay accelerating factor for complement (Cromer blood group)
    • Cd55a
    • Complement decay accelerating factor
    • Complement decay-accelerating factor
    • Complement decay-accelerating factor, GPI-anchored
    • CR
    • CROM
    • Cromer Blood Group antigen
    • Cromer blood group system
    • DAF
    • Daf-GPI
    • DAF_HUMAN
    • Daf1
    • Dcay accelerating factor for complement (CD55, Cromer blood group system)
    • Decay accelarating factor 1, isoform CRA_a
    • Decay accelerating factor (GPI-form)
    • Decay Accelerating Factor for Complement
    • Decay accelerating factor GPI-form
    • Decay accelerating factor soluble-form
    • GPI-DAF
    • TC
    see all
  • FunctionThis protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
  • Tissue specificityExpressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
  • Sequence similaritiesBelongs to the receptors of complement activation (RCA) family.
    Contains 4 Sushi (CCP/SCR) domains.
  • DomainThe first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3.
  • Post-translational
    modifications
    The Ser/Thr-rich domain is heavily O-glycosylated.
  • Cellular localizationCell membrane.
  • Information by UniProt

Recombinant Human CD55 protein images

  • 20% SDS PAGE gel, Commassie blue staining.

References for Recombinant Human CD55 protein (ab80038)

ab80038 has not yet been referenced specifically in any publications.

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