Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLE QKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM
    • Molecular weight
      21 kDa including tags
    • Amino acids
      73 to 232
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab156328 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >90% by SDS-PAGE.
    ab156328 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • CD 74
    • CD74
    • CD74 antigen
    • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
    • CD74 molecule
    • CD74 molecule, major histocompatibility complex, class II invariant chain
    • CLIP
    • DHLAG
    • Gamma chain of class II antigens
    • HG2A_HUMAN
    • HLA class II histocompatibility antigen gamma chain
    • HLA DR antigens associated invariant chain
    • HLA DR gamma
    • HLA-DR antigens-associated invariant chain
    • HLA-DR-gamma
    • HLADG
    • HLADR antigens associated invariant chain
    • Ia antigen associated invariant chain
    • Ia antigen-associated invariant chain
    • Ia associated invariant chain
    • Ia gamma
    • Ii
    • Invariant polypeptide of major histocompatibility complex class II antigen associated
    • la-gamma
    • Major histocompatibility complex class II invariant chain
    • MHC HLA DR gamma chain
    • MHC HLA-DR gamma chain
    • p33
    • p35
    • Protein 41
    see all
  • Function
    Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
  • Sequence similarities
    Contains 1 thyroglobulin type-1 domain.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab156328 (3µg).

References

ab156328 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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