The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. ab114161 is best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
alpha polypeptide (p32)
CD8 antigen alpha polypeptide
CD8 antigen alpha polypeptide (p32)
Leu2 T lymphocyte antigen
OKT8 T cell antigen
T cell antigen Leu2
T cell co receptor
T-cell surface glycoprotein CD8 alpha chain
T-lymphocyte differentiation antigen T8/Leu-2
T8 T cell antigen
T8/Leu-2 T-lymphocyte differentiation antigen
FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Involvement in diseaseDefects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.