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Source Wheat germ
Amino Acid Sequence
Sequence MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSL SELVVFWQDQENLVLNEVYLGKEKF
DSVHSKYMGRTSFDSDSWTLRLH NLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNIT EN
RLLSSPFSIELEDPQPPPD HIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQ TKKREK
Molecular weight 62 kDa including tags
Amino acids 1 to 329 Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notes Protein concentration is above or equal to 0.05 mg/ml
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.3% Glutathione, 0.79% Tris HCl
Activation B7-2 antigen
Activation B7-2 antigen 3
B-lymphocyte activation antigen B7-2
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Tissue specificity Expressed by activated B-lymphocytes and monocytes.
Sequence similarities Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Post-translational modifications Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Cellular localization Membrane.
Information by UniProt
Recombinant Human CD86 protein images
References for Recombinant Human CD86 protein (ab114228)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"