This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cell division cycle 25 homolog C
Cell division cycle 25C
Cell division cycle 25C protein
Dual specificity phosphatase Cdc25C
M phase inducer phosphatase 3
M-phase inducer phosphatase 3
Mitosis inducer CDC25
protein phosphatase 1, regulatory subunit 60
FunctionFunctions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
Sequence similaritiesBelongs to the MPI phosphatase family. Contains 1 rhodanese domain.
Developmental stageExpressed predominantly in G2 phase.
Post-translational modificationsPhosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.