Recombinant human CDC42 Binding Protein Kinase Beta (ab56638)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      1 to 473

Associated products

Specifications

Our Abpromise guarantee covers the use of ab56638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity: 120 nmol/min/mg.
  • Applications

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab204880 (RPS6 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CDC42 binding protein kinase beta
    • CDC42-binding protein kinase beta
    • CDC42BPB
    • DMPK like beta
    • DMPK-like beta
    • KIAA1124
    • MRCK beta
    • MRCKB_HUMAN
    • Myotonic dystrophy kinase related CDC42 binding kinase beta
    • Myotonic dystrophy kinase-related CDC42-binding kinase beta
    • Myotonic dystrophy protein kinase like beta
    • Myotonic dystrophy protein kinase-like beta
    • Serine/threonine protein kinase MRCK beta
    • Serine/threonine-protein kinase MRCK beta
    see all
  • Function
    May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
  • Tissue specificity
    Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 CNH domain.
    Contains 1 CRIB domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • Cellular localization
    Cytoplasm. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent.
  • Information by UniProt

Images

  • SDS Page analysis of ab56638
  • Kinase Assay: Specific Activity 120nmol/min/mg.

References

ab56638 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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