This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cdc2 related protein kinase
Cell division kinase 2
Cell division protein kinase 2
Cyclin dependent kinase 2
p33 protein kinase
RelevanceCDK2 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Cyclin A1 (CCNA1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.
Cellular localizationCCNA1: Nuclear
Recombinant human CDK2 + CCNA1 protein images
Functional Studies - CDK2 + CCNA1 protein (ab105205)
The Specific activity of ab105205 was determined to be 83 nmol/min/mg.
SDS-PAGE - CDK2 + CCNA1 protein (ab105205)
SDS-PAGE showing ab105205 at approximately 58 and 81kDa respectively.
References for Recombinant human CDK2 + CCNA1 protein (ab105205)
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