Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR
    • Molecular weight
      26 kDa including tags
    • Amino acids
      1 to 212
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab101667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 90 % SDS-PAGE.
    ab101667 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 40% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • CDI1
    • Cdk associated protein phosphatase
    • CDK2 associated dual specificity phosphatase
    • CDK2-associated dual-specificity phosphatase
    • CDKN3
    • CDKN3_HUMAN
    • CIP2
    • Cyclin dependent kinase inhibitor 3
    • Cyclin dependent kinase interacting protein 2
    • Cyclin dependent kinase interactor 1
    • Cyclin-dependent kinase inhibitor 3
    • Cyclin-dependent kinase interactor 1
    • Cyclin-dependent kinase-interacting protein 2
    • FLJ25787
    • KAP
    • KAP1
    • Kinase associated phosphatase
    • Kinase-associated phosphatase
    • MGC70625
    • OTTHUMP00000178991
    see all
  • Function
    May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
  • Involvement in disease
    Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family.
  • Cellular localization
    Cytoplasm > perinuclear region.
  • Information by UniProt

Images

  • ab101667 at 3 ug on an SDS-PAGE gel (15%)

References

ab101667 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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