May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Involvement in disease
Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].
Belongs to the protein-tyrosine phosphatase family.