Recombinant Human Cellular Apoptosis Susceptibility protein (ab114717)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      LIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMV NNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
    • Molecular weight
      37 kDa including tags
    • Amino acids
      872 to 971

Specifications

Our Abpromise guarantee covers the use of ab114717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • CAS
    • Cellular apoptosis susceptibility protein
    • Chromosome segregation 1 (yeast homolog) like
    • Chromosome segregation 1 Like
    • Chromosome segregation 1 like protein
    • Chromosome segregation 1-like protein
    • Chromosome segregation gene CSE1
    • CSE 1
    • CSE 1 chromosome segregation 1 like
    • CSE 1 chromosome segregation 1 like protein
    • CSE 1L
    • CSE1
    • CSE1 chromosome segregation 1 like
    • CSE1 chromosome segregation 1 like (yeast)
    • CSE1 chromosome segregation 1 like protein
    • CSE1L
    • Exp 2
    • Exp2
    • Exportin 2
    • Exportin-2
    • Exportin2
    • Importin alpha re exporter
    • Importin-alpha re-exporter
    • MGC117283
    • MGC130036
    • MGC130037
    • XPO 2
    • XPO2
    • XPO2_HUMAN
    see all
  • Function
    Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • Tissue specificity
    Highly expressed in proliferating cells.
  • Sequence similarities
    Belongs to the XPO2/CSE1 family.
    Contains 1 importin N-terminal domain.
  • Cellular localization
    Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114717 at approximately 36.63 kDa stained with Coomassie Blue.

References

ab114717 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab114717.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up