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Source Baculovirus infected Sf9 cells
Amino Acid Sequence
Tags His tag N-Terminus Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity ab73636 reacts with Scleroderma patient sera.
Purity > 90
% SDS-PAGE. ab73636 is purified by proprietary chromatographic techniques.
Additional notes ab73636 reacts with Scleroderma patient sera.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Constituents: 20% Glycerol, 250mM Sodium chloride, 20mM HEPES, pH 7.6
Function Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
Sequence similarities Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain.
Cellular localization Nucleus. Chromosome > centromere.
Information by UniProt
References for Recombinant Human CENPB protein (ab73636)
This product has been referenced in:
et al. Autoantibodies recognizing the amino terminal 1-17 segment of CENP-A display unique specificities in systemic sclerosis. PLoS One 8:e61453 (2013).
Read more (PubMed: 23613856) »
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for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"