• Product nameRecombinant Human CFTR protein
  • Protein lengthProtein fragment


  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP13569
    • SpeciesHuman
    • Molecular weight37 kDa including tags
    • Amino acids1381 to 1480


Our Abpromise guarantee covers the use of ab114246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications



    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 µg/µl
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • ABC 35
    • ABC35
    • ABCC 7
    • ABCC7
    • ATP binding cassette sub family C member 7
    • ATP Binding Cassette Superfamily C Member 7
    • ATP binding cassette transporter sub family C member 7
    • ATP-binding cassette sub-family C member 7
    • cAMP dependent chloride channel
    • cAMP-dependent chloride channel
    • CF
    • CFTR
    • CFTR/MRP
    • Channel conductance controlling ATPase
    • Channel conductance-controlling ATPase
    • Cystic fibrosis transmembrane conductance regulator
    • Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7)
    • Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7
    • Cystic Fibrosis Transmembrane Regulator
    • dJ760C5.1
    • MRP 7
    • MRP7
    • TNR CFTR
    see all
  • FunctionInvolved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
  • Tissue specificityFound on the surface of the epithelial cells that line the lungs and other organs.
  • Involvement in diseaseDefects in CFTR are the cause of cystic fibrosis (CF) [MIM:219700]; also known as mucoviscidosis. CF is the most common genetic disease in the Caucasian population, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive. CF is a common generalized disorder of exocrine gland function which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes.
    Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD) [MIM:277180]. CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • DomainThe PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
  • Post-translational
    Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites.
    Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling.
  • Cellular localizationEarly endosome membrane.
  • Information by UniProt

Recombinant Human CFTR protein images

  • 12.5% SDS-PAGE showing ab114246 at approximately 36.63kDa stained with Coomassie Blue.

References for Recombinant Human CFTR protein (ab114246)

ab114246 has not yet been referenced specifically in any publications.

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