Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionQ14839
    • SpeciesHuman
    • Molecular weight221 kDa including tags
    • Amino acids1 to 1912

Specifications

Our Abpromise guarantee covers the use of ab124864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity> 80 % SDS-PAGE.
    Purity is greater than 80% as determined by SDS-PAGE.
  • FormLiquid
  • Additional notes


    Binds IgG-type human auto-antibodies

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.38% HEPES, 20% Glycerol, 2.34% Sodium chloride

General Info

  • Alternative names
    • ATP dependent helicase CHD4
    • ATP-dependent helicase CHD4
    • CHD 4
    • CHD-4
    • CHD4
    • CHD4_HUMAN
    • Chromodomain helicase DNA binding protein 4
    • Chromodomain-helicase-DNA-binding protein 4
    • Mi 2 autoantigen 218 kDa protein
    • Mi 2b
    • Mi-2 autoantigen 218 kDa protein
    • Mi2 beta
    • Mi2-beta
    see all
  • FunctionComponent of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
  • Sequence similaritiesBelongs to the SNF2/RAD54 helicase family.
    Contains 2 chromo domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
    Contains 2 PHD-type zinc fingers.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Cytoplasm > cytoskeleton > centrosome. Associates with centrosomes in interphase.
  • Information by UniProt

References for Recombinant Human CHD4 protein (ab124864)

ab124864 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"