Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRTVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L

Specifications

Our Abpromise guarantee covers the use of ab78759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    ab78759 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM DTT, 20mM Tris, pH 8.0

General Info

  • Alternative names
    • Calcium and integrin binding 1 (calmyrin)
    • Calcium and integrin binding protein 1
    • Calcium and integrin-binding protein 1
    • Calcium- and integrin-binding protein
    • Calmyrin
    • CIB
    • CIB1
    • CIB1_HUMAN
    • CIBP
    • DNA PKcs interacting protein
    • DNA-dependent protein kinase interacting protein
    • DNA-PK interaction protein
    • DNA-PKcs-interacting protein
    • Human Snk interacting protein 2 to 28 mRNA complete cds
    • Kinase interacting protein
    • Kinase-interacting protein
    • Kinase-interacting protein 1
    • KIP
    • KIP1
    • PRKDCIP
    • SIP2 28
    • SIP2-28
    • SNK interacting protein 2 to 28
    • SNK-interacting protein 2-28
    see all
  • Function
    May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 2 EF-hand domains.
  • Cellular localization
    Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab78759 at approximately 23kDa (3µg).

References

ab78759 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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