Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO00299
    • SpeciesHuman
    • SequenceGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
    • Molecular weight29 kDa including tags
    • Amino acids1 to 241
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab119166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab119166 is purified by standard chromatography
  • FormLiquid
  • Additional notesPlease prevent freeze thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol

General Info

  • Alternative names
    • Chloride channel ABP
    • Chloride intracellular channel 1
    • Chloride intracellular channel protein 1
    • CLIC 1
    • CLIC1
    • CLIC1_HUMAN
    • G6
    • hRNCC
    • NCC 27
    • NCC27
    • Nuclear chloride ion channel 27
    • Nuclear chloride ion channel protein
    • p64CLCP
    • Regulatory nuclear chloride ion channel protein
    • RNCC protein
    see all
  • FunctionCan insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
  • Tissue specificityExpression is prominent in heart, placenta, liver, kidney and pancreas.
  • Sequence similaritiesBelongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • DomainMembers of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Post-translational
    modifications
    Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
  • Cellular localizationNucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt

References for Recombinant Human CLIC1 protein (ab119166)

ab119166 has not yet been referenced specifically in any publications.

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