Overview

  • Product name
    Recombinant Human COG7 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQE ANHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQD TSQSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVI SAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQA VDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSLDRQL TGLYDALLGAWHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSN GVERAGPEQELTRLLEFYDATAHFAKGLEMALLPHLHEHNLVKVTELVDA VYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQELSHSVNKLFG LASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLD HIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKY LSDSCSPRSLAGFQESILTDKKNSAKNPWQEYNYLQKDNPAEYASLMEIL YTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKM DSWNTAGIGETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDS ALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQI PELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLLKTRPEDYRQV SKGLPRRLATTVATMRSVNY
    • Amino acids
      1 to 770
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • CDG2E
    • COG complex subunit 7
    • cog7
    • COG7_HUMAN
    • Component of oligomeric Golgi complex 7
    • Conserved oligomeric Golgi complex component 7
    • Conserved oligomeric Golgi complex subunit 7
    see all
  • Function
    Required for normal Golgi function.
  • Involvement in disease
    Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the COG7 family.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt

Images

  • ab164887 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164887 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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