The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Alpha 2 collagen type I
Alpha 2 type I collagen
Alpha 2 type I procollagen
Alpha 2(I) collagen
Alpha 2(I) procollagen
Alpha-2 type I collagen
Collagen alpha 2(I) chain
Collagen alpha-2(I) chain
Collagen I alpha 2 polypeptide
Collagen of skin tendon and bone alpha 2 chain
Collagen type I alpha 2
Osteogenesis imperfecta type IV
Type I procollagen
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Involvement in disease
Ehlers-Danlos syndrome 7B Osteogenesis imperfecta 1 Osteogenesis imperfecta 2 Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form Osteogenesis imperfecta 3 Osteogenesis imperfecta 4 A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1.
Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain.
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Secreted > extracellular space > extracellular matrix.