Recombinant Human Constitutive androstane receptor protein (ab82072)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      101 to 348

Specifications

Our Abpromise guarantee covers the use of ab82072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    1 unit equals 1 nanogram of purified protein.
  • Applications

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • CAR
    • CAR BETA
    • CAR1
    • CARA
    • Constitutive activator of retinoid response
    • constitutive active receptor
    • Constitutive active response
    • constitutive androstane nuclear receptor variant 2
    • constitutive androstane nuclear receptor variant 3
    • constitutive androstane nuclear receptor variant 4
    • constitutive androstane nuclear receptor variant 5
    • Constitutive androstane receptor
    • MB67
    • MGC97144
    • NR1I3
    • NR1I3_HUMAN
    • Nuclear receptor subfamily 1 group I member 3
    • orphan nuclear hormone receptor
    • Orphan nuclear receptor MB67
    • Orphan nuclear receptor NR1I3
    see all
  • Function
    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
  • Tissue specificity
    Predominantly expressed in liver.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain
    Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
  • Post-translational
    modifications
    Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • Cellular localization
    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7.
  • Information by UniProt

References

ab82072 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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