Recombinant Human Constitutive androstane receptor protein (ab83193)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% Affinity purified
- Suitable for: Functional Studies
Description
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Product name
Recombinant Human Constitutive androstane receptor protein -
Biological activity
1 unit equals 1 nanogram of purified protein. -
Purity
> 90 % Affinity purified.
Recombinant ab83193 was expressed in a E.coli system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 90% homogeneous and contains no detectable protease, DNase and RNase activity. -
Expression system
Escherichia coli -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human
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Specifications
Our Abpromise guarantee covers the use of ab83193 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Functional Studies
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Form
Liquid -
Additional notes
1 unit equals 1 nanogram of purified protein. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.9
Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol (glycerin, glycerine)
General Info
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Alternative names
- CAR
- CAR BETA
- CAR1
see all -
Function
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. -
Tissue specificity
Predominantly expressed in liver. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Domain
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. -
Post-translational
modificationsPhosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. -
Cellular localization
Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab83193 has not yet been referenced specifically in any publications.