Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      HMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKM LNKFTKSGLKSQFAYCMLIRIASRLLKETEDGH
    • Amino acids
      165 to 247
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 2 COP
    • Coat protein nonclathrin gamma 2 cop
    • Coatomer protein complex subunit gamma 2
    • Coatomer subunit gamma 2
    • Coatomer subunit gamma-2
    • COPG 2
    • Copg2
    • COPG2_HUMAN
    • DKFZp761N09121
    • FLJ11781
    • Gamma 2 coat protein
    • Gamma 2 COP
    • Gamma-2-coat protein
    • Gamma-2-COP
    see all
  • Function
    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
  • Sequence similarities
    Belongs to the COPG family.
    Contains 6 HEAT repeats.
  • Cellular localization
    Cytoplasm, cytosol. Golgi apparatus membrane. Cytoplasmic vesicle, COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.
  • Information by UniProt

Images

  • ab162043 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162043 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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