Overview

  • Product name
    Recombinant Human COPZ1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P61923
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMEALILEPSLYTVKAILILDNDGDRLFAKY YDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVI GSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVD GGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR
    • Molecular weight
      22 kDa including tags
    • Amino acids
      1 to 177
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab107148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    ab107148 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • 5930435A22Rik
    • AA407760
    • CGI 120
    • Coatomer protein complex subunit zeta 1
    • Coatomer subunit zeta 1
    • Coatomer subunit zeta-1
    • COPZ
    • COPZ 1
    • COPZ1
    • COPZ1_HUMAN
    • D4Ertd360e
    • HSPC181
    • MGC118060
    • Zeta 1 coat protein
    • zeta 1 COP
    • zeta COP
    • Zeta-1 COP
    • Zeta-1-coat protein
    • Zeta1 COP
    see all
  • Function
    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
    The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
  • Sequence similarities
    Belongs to the adaptor complexes small subunit family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
  • Information by UniProt

Images

  • SDS-PAGE - COPZ1 protein (ab107148)
    SDS-PAGE - COPZ1 protein (ab107148)
    15% SDS-PAGE showing ab107148 (3µg).

References

ab107148 has not yet been referenced specifically in any publications.

Publishing research using ab107148? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Submit a review Submit a question

There are currently no Customer reviews or Questions for ab107148.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up