The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
activated protease fragment
Atrial natriuretic peptide-converting enzyme
Atrial natriuteric peptide converting enzyme
Corin serine peptidase
Heart specific serine proteinase
Heart specific serine proteinase ATC2
Heart-specific serine proteinase ATC2
Pro ANP convertase
Pro ANP converting enzyme
Transmembrane protease serine 10
Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
Highly expressed in heart. Expressed in heart myocytes.
Belongs to the peptidase S1 family. Contains 2 FZ (frizzled) domains. Contains 7 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Contains 1 SRCR domain.
N-glycosylated; required for processing and activation. Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.