Recombinant Human Cornulin protein (ab93883)
Key features and details
- Expression system: Escherichia coli
- Purity: > 85% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human Cornulin protein -
Purity
> 85 % SDS-PAGE.
Purified using conventional chromatography techniques -
Expression system
Escherichia coli -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Amino acids
1 to 495
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab93883 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 7.40
Constituents: 10% Glycerol (glycerin, glycerine), PBS
General Info
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Alternative names
- 53 kDa putative calcium binding protein
- 53 kDa putative calcium-binding protein
- 53 kDa squamous epithelial induced stress protein
see all -
Function
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. -
Tissue specificity
Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). -
Sequence similarities
Belongs to the S100-fused protein family.
Contains 1 EF-hand domain. -
Domain
The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA. -
Cellular localization
Cytoplasm. Does not colocalize with TGM1. - Information by UniProt
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab93883 has not yet been referenced specifically in any publications.