Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITF QHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMR PLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQV YDLPGILAQLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLAS CAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAI LTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHP GLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFY VDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS
    • Amino acids
      1 to 443
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 2410004F01Rik
    • AU042636
    • COX10
    • COX10_HUMAN
    • Cytochrome c oxidase assembly protein
    • Cytochrome c oxidase subunit X
    • Heme A farnesyltransferase
    • Heme O synthase
    • OTTMUSP00000006085
    • Protoheme IX farnesyltransferase, mitochondrial
    • Protoheme IX farnesyltransferase, mitochondrial precursor
    • RP23-78H18.1
    see all
  • Function
    Converts protoheme IX and farnesyl diphosphate to heme O.
  • Involvement in disease
    Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
  • Sequence similarities
    Belongs to the ubiA prenyltransferase family.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt

Images

  • ab158183 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158183 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab158183.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up