Recombinant Human CPI17 alpha protein (ab119161)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC GKPVEDFIQE LLAKLQGLHR QPGLRQPSPS HDGSLSPLQD RARTAHP
    • Molecular weight
      18 kDa including tags
    • Amino acids
      1 to 147
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab119161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    ab119161 is purified by proprietary chromatographic techniques. Purity was determined to be greater than 95% as determined by RP-HPLC and SDS-PAGE.
  • Form
    Liquid
  • Additional notes
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.06% EDTA, 0.02% DTT, 10% Glycerol

General Info

  • Alternative names
    • 17 kDa PKC-potentiated inhibitory protein of PP1
    • 17-KDa protein
    • 17kDa PKC potentiated inhibitory protein of PP1
    • CPI 17
    • CPI 17 alpha
    • CPI 17alpha
    • CPI-17
    • CPI17
    • PKC potentiated inhibitory protein of PP1
    • PKC potentiated inhibitory protein of PP1, 17-KD
    • PP14A_HUMAN
    • PPP1INL
    • Ppp1r14a
    • Protein kinase C-potentiated inhibitor of protein phosphatase 1, 17-KD
    • Protein kinase C-potentiated inhibitor protein of 17 kDa
    • Protein phosphatase 1
    • Protein phosphatase 1 regulatory (inhibitor) subunit 14A
    • Protein phosphatase 1 regulatory subunit 14A
    • Regulatory subunit 14A
    see all
  • Function
    Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
  • Tissue specificity
    Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
  • Sequence similarities
    Belongs to the PP1 inhibitor family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab119161 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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