Calcitonin gene related peptide receptor component
Calcitonin gene related peptide receptor component protein
Calcitonin gene-related peptide-receptor component protein
CGRP receptor component protein
CGRP-receptor component protein
DNA-directed RNA polymerase III subunit RPC9
RNA polymerase III subunit C9
FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway. Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
Tissue specificityUbiquitous. Most prevalent in testis.
Sequence similaritiesBelongs to the eukaryotic RPC9 RNA polymerase subunit family.