Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP41240
    • SpeciesHuman
    • Molecular weight50 kDa
    • Amino acids1 to 450
    • TagsHis tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab82187 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • C SRC
    • C SRC kinase
    • C src Tyrosine Kinase
    • C-SRC kinase
    • c-src tyrosine kinase
    • CSK
    • Csk A
    • CSK_HUMAN
    • CYTOPLASMIC TYROSINE KINASE
    • EC 2.7.10.2
    • MGC112926
    • MGC117393
    • MGC154049
    • P60 Src
    • Protein tyrosine kinase CYL
    • Protein-tyrosine kinase CYL
    • Proto oncogene tyrosine protein kinase
    • Tyrosine protein kinase CSK
    • Tyrosine-protein kinase CSK
    • zgc:154049
    see all
  • FunctionSpecifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
  • Tissue specificityExpressed in lung and macrophages.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Post-translational
    modifications
    Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
  • Cellular localizationCytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
  • Information by UniProt

References for Recombinant Human CSK protein (ab82187)

ab82187 has not yet been referenced specifically in any publications.

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