The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
conserved gene amplified in osteosarcoma
conserved gene amplified in osteosarcoma 4
NLI interacting factor 2
NLI-interacting factor 2
Nuclear LIM interactor interacting factor 2
Nuclear LIM interactor-interacting factor 2
Protein OS 4
Small C-terminal domain phosphatase 2
Small CTD phosphatase 2
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.