Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTD small phosphatase-like protein
NLI-interacting factor 1
Nuclear LIM interactor-interacting factor 1
RB protein serine phosphatase from chromosome 3
Small C-terminal domain phosphatase 3
Small CTD phosphatase 3
FunctionPreferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Tissue specificityExpression is restricted to non-neuronal tissues.