Small inducible cytokine subfamily D (Cys X3 Cys) member 1
small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
Small inducible cytokine subfamily D member 1
Small-inducible cytokine D1
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
Belongs to the intercrine delta family.
A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. O-glycosylated with core 1 or possibly core 8 glycans.