The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBiological Activity:
ED50 range = 1.0-10 ng/mL, determined by the dose dependent chemotaxis of human lymphocytes cultured in the presence of IL2.
% SDS-PAGE. ab73838 is purified by proprietary chromatographic techniques. Purity is greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution ab73838 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
C-X-C motif chemokine 11
Chemokine (C-X-C motif) ligand 11
Chemokine C-X-C motif ligand 11
Interferon gamma inducible protein 9
Interferon gamma-inducible protein 9
Interferon inducible T cell alpha chemoattractant
Interferon-inducible T-cell a chemoattractant I-TAC
Interferon-inducible T-cell alpha chemoattractant
Small inducible cytokine B11
Small inducible cytokine subfamily B (Cys-X-Cys) member 11
Small inducible cytokine subfamily B (Cys-X-Cys) member 9B
Small inducible cytokine subfamily B, member 11
Small inducible cytokine subfamily B, member 9B
Small-inducible cytokine B11
FunctionChemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Tissue specificityHigh levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.