The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBiological Activity : Determined by it's ability to chemoattract activated lymphocytes using a concentration of 1.0-100.0 ng/ml.
Endotoxin level< 0.100 Eu/µg
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Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute to 1mg/ml in sterile water.
C-X-C motif chemokine 16
Chemokine (C X C motif) ligand 16
Chemokine, CXC motif, ligand 16
CXC chemokine ligand 16
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Small inducible cytokine B16 precursor
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
FunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Tissue specificityExpressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
Cellular localizationCell membrane. Secreted. Also exists as a soluble form.