Recombinant Human Cyclin C protein (ab59893)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab59893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Immunoprecipitation

    ELISA

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.5% Triton-X-100, 25mM HEPES, 125mM Potassium chloride, pH 7.9

General Info

  • Alternative names
    • ccnc
    • CCNC_HUMAN
    • CycC
    • Cyclin C
    • Cyclin-C
    • hSRB11
    • OTTHUMP00000016897
    • SRB11 homolog
    see all
  • Function
    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • Tissue specificity
    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • Sequence similarities
    Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Recombinant Human Cyclin C protein (ab59893)

ab59893 has not yet been referenced specifically in any publications.

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