Recombinant Human Cyclin D2 protein (denatured) (ab116405)

Overview

  • Product nameRecombinant Human Cyclin D2 protein (denatured)
  • Protein lengthFull length protein
  • Description
    Recombinant Human Cyclin D2 protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP30279
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMELLCH EVDPVRRAVR DRNLLRDDRV LQNLLTIEER YLPQCSYFKC VQKDIQPYMR RMVATWMLEV CEEQKCEEEV FPLAMNYLDR FLAGVPTPKS HLQLLGAVCM FLASKLKETS PLTAEKLCIY TDNSIKPQEL LEWELVVLGK LKWNLAAVTP HDFIEHILRK LPQQREKLSL IRKHAQTFIA LCATDFKFAM YPPSMIATGS VGAAICGLQQ DEEVSSLTCD ALTELLAKIT NTDVDCLKAC QEQIEAVLLN SLQQYRQDQR DGSKSEDELD QASTPTDVRD IDL
    • Molecular weight36 kDa including tags
    • Amino acids1 to 289
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab116405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 85 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 83% Tris HCl, 6% Urea, 0.03% DTT, 10% Glycerol

General Info

  • Alternative names
    • CCND 2
    • ccnd2
    • CCND2_HUMAN
    • CyclinD2
    • G1/S specific cyclin D2
    • G1/S-specific cyclin-D2
    • KIAK0002
    • MGC102758
    see all
  • FunctionRegulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
  • Sequence similaritiesBelongs to the cyclin family. Cyclin D subfamily.
    Contains 1 cyclin N-terminal domain.
  • Cellular localizationNucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
  • Information by UniProt

Recombinant Human Cyclin D2 protein (denatured) images

  • 3ug Cyclin D2 protein. 15% SDS-PAGE

References for Recombinant Human Cyclin D2 protein (denatured) (ab116405)

ab116405 has not yet been referenced specifically in any publications.

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