FunctionMay play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
Tissue specificityHigh levels in skeletal muscle, ovary, kidney and colon.
Sequence similaritiesBelongs to the cyclin family. Cyclin G subfamily.
Developmental stageVery low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.
Cellular localizationNucleus. DNA replication foci after DNA damage.