FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.
Tissue specificityFound in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence similaritiesBelongs to the cyclophilin-type PPIase family. PPIase E subfamily. Contains 1 PPIase cyclophilin-type domain. Contains 1 RRM (RNA recognition motif) domain.