The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cholesterol 20 22 desmolase
Cholesterol monooxygenase (side chain cleaving)
Cholesterol side chain cleavage enzyme
Cholesterol side chain cleavage enzyme mitochondrial
Cholesterol side-chain cleavage enzyme
Cytochrome P450 11A1
Cytochrome P450 11A1 mitochondrial
Cytochrome P450 family 11 subfamily A polypeptide 1
Cytochrome P450 subfamily XIA
Steroid 20 22 lyase
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Lipid metabolism; C21-steroid hormone metabolism.
Involvement in disease
Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI). Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.