The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cytochrome P450 26A2
Cytochrome P450 26B1
Cytochrome P450 family 26 subfamily B polypeptide 1
Cytochrome P450 retinoic acid-inactivating 2
Cytochrome P450 retinoid metabolizing protein
Cytochrome P450 subfamily XXVIA, polypeptide 2
Cytochrome P450 subfamily XXVIB polypeptide 1
P450 retinoic acid inactivating 2
Retinoic acid metabolizing cytochrome
Retinoic acid-metabolizing cytochrome
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Highly expressed in brain, particularly in the cerebellum and pons.
Involvement in disease
Radiohumeral fusions with other skeletal and craniofacial anomalies