Recombinant Human Cytokeratin 10 protein (ab114223)

Overview

  • Product nameRecombinant Human Cytokeratin 10 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP13645
    • SpeciesHuman
    • SequenceKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLA ETEGRYCVQLSQIQAQISALEEQLQ QIRAETECQNTEYQQLLDIKIRL ENEIQTYRSLLE
    • Molecular weight38 kDa including tags
    • Amino acids345 to 454

Specifications

Our Abpromise guarantee covers the use of ab114223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • BCIE
    • BIE
    • CK 10
    • CK-10
    • Cytokeratin-10
    • EHK
    • K10
    • K1C10_HUMAN
    • Keratin
    • Keratin 10
    • Keratin type i cytoskeletal 10
    • Keratin type I cytoskeletal 59 kDa
    • Keratin-10
    • Keratin10
    • KPP
    • KRT10
    • type I cytoskeletal 10
    see all
  • Tissue specificitySeen in all suprabasal cell layers including stratum corneum.
  • Involvement in diseaseDefects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
    Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Information by UniProt

Recombinant Human Cytokeratin 10 protein images

  • ab114223 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References for Recombinant Human Cytokeratin 10 protein (ab114223)

ab114223 has not yet been referenced specifically in any publications.

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