Recombinant Human Cytokeratin 16 protein (ab114405)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      RRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQ LSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQ
    • Molecular weight
      36 kDa including tags
    • Amino acids
      301 to 398

Specifications

Our Abpromise guarantee covers the use of ab114405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • CK 16
    • CK-16
    • CK16
    • Cytokeratin-16
    • Cytokeratin16
    • FNEPPK
    • Focal non epidermolytic palmoplantar keratoderma
    • K 16
    • K16
    • K1C16_HUMAN
    • K1CP
    • Keratin
    • Keratin 1 type I
    • Keratin 16
    • Keratin type I cytoskeletal 16
    • Keratin-16
    • Keratin16
    • KRT 16
    • Krt16
    • KRT16A
    • NEPPK
    • PC1
    • type I cytoskeletal 16
    see all
  • Tissue specificity
    Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
  • Involvement in disease
    Defects in KRT16 are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
    Defects in KRT16 are the cause of palmoplantar keratoderma non-epidermolytic focal (FNEPPK) [MIM:613000]. A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
    Defects in KRT16 are a cause of unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]. UPVN is characterized by a localized thickening of the skin in parts of the right palm and the right sole.
    Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab114405, stained with Coomassie Blue.

References

ab114405 has not yet been referenced specifically in any publications.

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