Recombinant Human Cytokeratin 18 protein (ab53663)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab53663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, PBS

General Info

  • Alternative names
    • Cell proliferation inducing gene 46 protein
    • Cell proliferation inducing protein 46
    • Cell proliferation-inducing gene 46 protein
    • CK 18
    • CK-18
    • CK18
    • CYK 18
    • CYK18
    • Cytokeratin 18
    • Cytokeratin endo B
    • Cytokeratin-18
    • K 18
    • K18
    • K1C18_HUMAN
    • KA18
    • Keratin 18
    • Keratin 18, type I
    • Keratin D
    • keratin, type I cytoskeletal 18
    • Keratin-18
    • Krt18
    see all
  • FunctionInvolved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
  • Tissue specificityExpressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
  • Involvement in diseaseDefects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600].
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Post-translational
    modifications
    Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
    Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
    O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.
  • Cellular localizationCytoplasm > perinuclear region.
  • Information by UniProt

Recombinant Human Cytokeratin 18 protein images

  • ab53663 on SDS-PAGE

References for Recombinant Human Cytokeratin 18 protein (ab53663)

ab53663 has not yet been referenced specifically in any publications.

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