Recombinant Human Cytokeratin 3 protein (ab114414)

Overview

  • Product nameRecombinant Human Cytokeratin 3 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP12035
    • SpeciesHuman
    • SequenceLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMED LVEDFKKK
    • Molecular weight32 kDa including tags
    • Amino acids232 to 289

Specifications

Our Abpromise guarantee covers the use of ab114414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 65 kDa cytokeratin
    • CK-3
    • CK3
    • Cytokeratin-3
    • K2C3_HUMAN
    • K3
    • Keratin
    • Keratin 3
    • Keratin type II cytoskeletal 3
    • Keratin-3
    • KRT3
    • type II cytoskeletal 3
    • Type-II keratin Kb3
    see all
  • Tissue specificityCornea specific.
  • Involvement in diseaseDefects in KRT3 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated as MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Information by UniProt

Recombinant Human Cytokeratin 3 protein images

  • 12.5% SDS-PAGE stained with Coomassie Blue.

References for Recombinant Human Cytokeratin 3 protein (ab114414)

ab114414 has not yet been referenced specifically in any publications.

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