Recombinant human DAP Kinase 1 protein (ab63191)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      1 to 363

Associated products

Specifications

Our Abpromise guarantee covers the use of ab63191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity: 49 nmol/min/mg.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • DAK1
    • DAP K1
    • DAP kinase 1
    • DAPK
    • DAPK 1
    • DAPK1
    • DAPK1_HUMAN
    • Death Associated Protein Kinase 1
    • Death-associated protein kinase 1
    • DKFZp781I035
    see all
  • Function
    Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
    Contains 10 ANK repeats.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.
  • Cellular localization
    Cytoplasm. Colocalizes with the actin filament system.
  • Information by UniProt

Images

  • Sample Kinase Activity Plot.
  • ab63191 on SDS-PAGE. Molecular Weight: ~71 kDa.

References

ab63191 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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