This product is an active protein and may elicit a biological response in vivo, handle with caution.
CaMK-like CREB regulatory kinase 2
Doublecortin and CaM kinase like 2
Doublecortin domain-containing protein 3B
Doublecortin like and CAM kinase like 2
Doublecortin like kinase 2
Doublecortin-like and CAM kinase-like 2
Doublecortin-like kinase 2
Serine/threonine protein kinase DCLK2
Serine/threonine-protein kinase DCLK2
FunctionProtein kinase with a significantly reduced Ca2+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 2 doublecortin domains. Contains 1 protein kinase domain.
DomainThe doublecortin domains are involved in the colocalization with microtubules.
Cellular localizationCytoplasm > cytoskeleton. Colocalizes with microtubules.