Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      23 kDa
    • Amino acids
      7 to 212
    • Tags
      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127294 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names
    • DCDC 2
    • DCDC2
    • DCDC2_HUMAN
    • DCDC2A
    • Doublecortin domain containing 2
    • doublecortin domain containing protein 2
    • Doublecortin domain-containing protein 2
    • HGNC:18141
    • KIAA1154
    • Protein RU2S
    • RU 2
    • RU2
    • RU2S
    • RU2S protein
    see all
  • Function
    May be involved in neuronal migration during development of the cerebral neocortex.
  • Tissue specificity
    Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus.
  • Involvement in disease
    Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.
  • Sequence similarities
    Contains 2 doublecortin domains.
  • Information by UniProt

References for Recombinant Human DCDC2 protein (ab127294)

ab127294 has not yet been referenced specifically in any publications.

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