Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSMATPPKRSCPSFSASS EGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQD EFEELTMSQKNGGNVLQMMYEKPERWSFTF QTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESEC MNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNE EQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKY ESLVEKVKEFLSTL
    • Molecular weight
      34 kDa including tags
    • Amino acids
      1 to 260
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab173027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituent: 0.24% Tris

    Supplied as a 0.2 µM filtered solution.

General Info

  • Alternative names
    • dCK
    • DCK protein
    • DCK_HUMAN
    • Deoxycytidine kinase
    • Deoxynucleoside kinase
    • EC 2.7.1
    • EC 2.7.1.74
    • MGC117410
    • MGC138632
    • OTTHUMP00000219118
    • OTTHUMP00000219119
    see all
  • Function
    Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
  • Sequence similarities
    Belongs to the DCK/DGK family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab173027 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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