The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% by SDS-PAGE. ab113138 was purified using conventional chromatography.
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Preparation and Storage
Stability and Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Mix suspension via gentle inversion before use.
pH: 8.00 Constituents: 0.32% Tris HCl, 20% Glycerol, 0.02% DTT
Decapping enzyme scavenger
heat shock-like protein 1
Hint related 7meGMP directed hydrolase
Hint-related 7meGMP-directed hydrolase
Histidine triad protein member 5
homolog of C. elegans 7meGMP-directed hydrolase dcs-1
mRNA decapping enzyme
Scavenger mRNA decapping enzyme DcpS
Scavenger mRNA-decapping enzyme DcpS
FunctionNecessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
Tissue specificityDetected in liver, brain, kidney, testis and prostate.