DCN1 defective in cullin neddylation 1 domain containing 1
DCN1 like protein 1
DCUN1 domain containing protein 1
Defective in cullin neddylation protein 1 like protein 1
Squamous cell carcinoma related oncogene
RelevanceDCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas.
Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
Recombinant Human DCUN1D1 protein images
SDS-PAGE - DCUN1D1 protein (ab103056)
15% SDS-PAGE (3 µg)
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