The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
DCN1 defective in cullin neddylation 1 domain containing 3
DCN1 defective in cullin neddylation 1 domain containing 3 (S. cerevisiae)
DCN1 like protein 3
DCN1-like protein 3
DCUN1 domain containing protein 3
DCUN1 domain-containing protein 3
Defective in cullin neddylation protein 1 like protein 3
Defective in cullin neddylation protein 1-like protein 3
Squamous cell carcinoma-related oncogene 3
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).
Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma.
Contains 1 DCUN1 domain.
The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.