Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ7Z4W1
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
    • Molecular weight28 kDa including tags
    • Amino acids1 to 244
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab117694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab117694 is purified by proprietary chromatographic techniques
  • FormLiquid
  • Additional notesPlease prevent freeze thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.29% Sodium chloride, 20% Glycerol

General Info

  • Alternative names
    • Carbonyl reductase 2
    • Carbonyl reductase II
    • DCR
    • Dcxr
    • DCXR_HUMAN
    • Dicarbonyl L xylulose reductase
    • Dicarbonyl/ L xylulose reductase
    • Dicarbonyl/L-xylulose reductase
    • HCR2
    • HCRII
    • Human carbonyl reductase 2
    • kiDCR
    • Kidney dicarbonyl reductase
    • L xylulose reductase
    • L-xylulose reductase
    • P34H
    • PNTSU
    • SDR20C1
    • Short chain dehydrogenase/reductase family 20C member 1
    • Sperm surface protein P34H
    • XR
    see all
  • FunctionCatalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
  • Tissue specificityHighly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
  • Involvement in diseaseNote=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
  • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localizationMembrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
  • Information by UniProt

References for Recombinant Human DCXR protein (ab117694)

ab117694 has not yet been referenced specifically in any publications.

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